DIFFERENTIAL PHARMACODYNAMIC EFFECTS ON PSORIATIC BIOMARKERS BY GUSELKUMAB VERSUS SECUKINUMAB CORRELATE WITH LONG-TERM EFFICACY: AN ECLIPSE SUBSTUDY

Differential Pharmacodynamic Effects on Psoriatic Biomarkers by Guselkumab Versus Secukinumab Correlate with Long-Term Efficacy: An ECLIPSE Substudy

IL-23 is a cytokine produced by myeloid cells that drives the T helper 17 pathway and plays an essential role in the pathophysiology of plaque psoriasis.IL-23 activation initiates a cascade of cytokines subsequently inducing the expression of many psoriasis-related proteins.This study aimed to better understand TV CUPBOARD the underlying mechanisms

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Psychological Impact of the COVID-19 Pandemic on Frontline Health Care Workers During the Pandemic Surge in New York City

Background This study sought to assess the magnitude of and factors associated with mental health outcomes among frontline health care workers (FHCWs) providing care during the Spring 2020 COVID-19 pandemic surge in New York City.Methods A cross-sectional, survey-based study over 4 weeks during the Spring 2020 pandemic surge was used to assess symp

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Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis.

Neonatal necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of preterm infants.Increased intestinal epithelium permeability is an early event in NEC pathogenesis.Autophagy and apoptosis are induced by multiple stress pathways which may impact the intestinal barrier, and they have been associated with pathogenesis of diverse g

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