Differential Pharmacodynamic Effects on Psoriatic Biomarkers by Guselkumab Versus Secukinumab Correlate with Long-Term Efficacy: An ECLIPSE Substudy
IL-23 is a cytokine produced by myeloid cells that drives the T helper 17 pathway and plays an essential role in the pathophysiology of plaque psoriasis.IL-23 activation initiates a cascade of cytokines subsequently inducing the expression of many psoriasis-related proteins.This study aimed to better understand TV CUPBOARD the underlying mechanisms